background: experimental autoimmune encephalomyelitis (eae) is an animal model of multiple sclerosis, which is a demyelinating and an inflammatory disease of central nervous system. recent studies have established that some molecules such as lipocaline2 (lcn2), which expresses during inflammatory conditions, play an important role in eae pathogenesis and might involve in its treatment process. r...

background: multiple sclerosis (ms) is known as a progressive central nervous system inflammatory disease. certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in ms etiology. because of the important role of oxidative stress, antioxidant therapy for ms has received more attention. although coenzyme q10 (coq10) acts as an antioxidant, there is ...

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

objective: this study investigated the effects of adipose-derived mesenchymal stem cells (mscs) and conditioned medium injection on cell infiltration in the brains of an experimental c57bl/6 mice model of autoimmune encephalomyelitis (eae). methods: eae was induced with myelin oligodendrocyte glycoprotein (35-55 peptides) in 20 mice. mscs were obtained from the adipose tissue of c57bl/6 mice a...

multiple sclerosis (ms) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. extracellular matrix (ecm) have important role in the central nervous system (cns). alterations are happening to the ecm after the cns disorder like ms, alzheimer and other neural injury. tenasin-c (tnc) is a glycoprotein that is highly expressed in inflammatory conditions of the cns...

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...

multiple sclerosis (ms) and its animal model, experimental autoimmune encephalomyelitis (eae), are chronic inflammatory demyelinating disorders of central nervous system (cns). while the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. one of the approaches being proposed in eae therapy is neural stem cells (nscs) trans...

Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). MS is also named encephalomyelitis disseminata (ED). EAE has been also called experimental allergic encephalomyelitis, but the word `allergic` is more and more replaced by the word `autoimmune`. This has to do with the deeper understanding of the disease biology that has been gathered over the last ye...

to understand the mechanism of multiple sclerosis (ms), an autoimmune demyelinating disease, the researchers developed an experimental animal model for ms, which is called eae (experimental allergic encephalomyelitis). there are several methods for inducing this animal model. in this research the active eae, which is developed by injecting bovine myelin antigens into genetically susceptible ani...